Melatonin Improves Short-Term Spatial Memory in a Mouse Model of Alzheimer's Disease.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is a neurodegenerative disease that has become a leading cause of death in recent years. Impairments in spatial learning and memory are an important clinical feature of AD. Melatonin (MLT), the main product secreted by the pineal gland, showed multiple antioxidant, anti-inflammatory, and neuroprotective properties.

Purpose

The present study aimed to explore the possible prophylactic effects of MLT against spatial memory deficits in a sporadic mouse model of AD induced by D-galactose and aluminium chloride (AlCl₃).

Methods

Four groups of mice (n = 10 per group) were prepared: control, AD (the D-galactose and AlCl₃ AD model group), AD+MLT (AD mice treated with 80 mg/kg MLT), and AD+DON (AD mice treated w

SUBMITTER: Labban S 

PROVIDER: S-EPMC8110255 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature