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To cut or not to cut: New rules for proteolytic shedding of membrane proteins.

ABSTRACT: Sheddases are specialized proteases that control the abundance and function of membrane proteins by cleaving their substrate's extracellular domain (ectodomain), a process known as shedding. Hundreds of shedding substrates have been identified, but little is known about the mechanisms that govern ectodomain shedding. Iwagishi et al. now report that negatively charged amino acids in the membrane-proximal juxtamembrane domain of substrates make them resistant to shedding by the metalloprotease ADAM17. These findings will help researchers better understand the regulation of shedding and may aid in the development of drugs targeting sheddases.

SUBMITTER: Lichtenthaler SF

PROVIDER: S-EPMC7458817 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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To cut or not to cut: New rules for proteolytic shedding of membrane proteins.

Lichtenthaler Stefan F SF Meinl Edgar E

The Journal of biological chemistry 20200801 35

Sheddases are specialized proteases that control the abundance and function of membrane proteins by cleaving their substrate's extracellular domain (ectodomain), a process known as shedding. Hundreds of shedding substrates have been identified, but little is known about the mechanisms that govern ectodomain shedding. Iwagishi <i>et al.</i> now report that negatively charged amino acids in the membrane-proximal juxtamembrane domain of substrates make them resistant to shedding by the metalloprote ...[more]

PMID: 32859721

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