Ontology highlight
ABSTRACT:
SUBMITTER: Kohler CU
PROVIDER: S-EPMC7459535 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Köhler Christina U CU Walter Michael M Lang Kerstin K Plöttner Sabine S Roghmann Florian F Noldus Joachim J Tannapfel Andrea A Tam Yu Chun YC Käfferlein Heiko U HU Brüning Thomas T
Biomedicines 20200722 8
We identified DNA methylation targets specific for urothelial cancer (UC) by genome-wide methylation difference analysis of human urothelial (RT4, J82, 5637), prostate (LNCAP, DU-145, PC3) and renal (RCC-KP, CAKI-2, CAL-54) cancer cell lines with their respective primary epithelial cells. A large overlap of differentially methylated targets between all organs was observed and 40 Cytosine-phosphate-Guanine motifs (CpGs) were only specific for UC cells. Of those sites, two also showed high methyla ...[more]