Ontology highlight
ABSTRACT:
SUBMITTER: Felle M
PROVIDER: S-EPMC3167622 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Felle Max M Hoffmeister Helen H Rothammer Julia J Fuchs Andreas A Exler Josef H JH Längst Gernot G
Nucleic acids research 20110527 16
Positioned nucleosomes limit the access of proteins to DNA. However, the impact of nucleosomes on DNA methylation in vitro and in vivo is poorly understood. Here, we performed a detailed analysis of nucleosome binding and nucleosomal DNA methylation by the de novo methyltransferases. We show that compared to linker DNA, nucleosomal DNA is largely devoid of CpG methylation. ATP-dependent chromatin remodelling frees nucleosomal CpG dinucleotides and renders the remodelled nucleosome a 2-fold bette ...[more]