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Prenylated Flavonoids from the Roots of Tephrosia rhodesica.

ABSTRACT: Five new compounds-rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)-along with 16 known secondary metabolites, were isolated from the CH2Cl2-CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2-5, 9, 15, and 21 showed activity (100% at 10 ?g and IC50 = 5-15 ?M) against the chloroquine-sensitive (3D7) strain of Plasmodium falciparum.

SUBMITTER: Atilaw Y

PROVIDER: S-EPMC7460544 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Prenylated Flavonoids from the Roots of Tephrosia rhodesica.

Atilaw Yoseph Y Muiva-Mutisya Lois L Bogaerts Jonathan J Duffy Sandra S Valkonen Arto A Heydenreich Matthias M Avery Vicky M VM Rissanen Kari K Erdélyi Máté M Yenesew Abiy A

Journal of natural products 20200813 8

Five new compounds-rhodimer (1), rhodiflavan A (2), rhodiflavan B (3), rhodiflavan C (4), and rhodacarpin (5)-along with 16 known secondary metabolites, were isolated from the CH2Cl2-CH3OH (1:1) extract of the roots of Tephrosia rhodesica. They were identified by NMR spectroscopic, mass spectrometric, X-ray crystallographic, and ECD spectroscopic analyses. The crude extract and the isolated compounds 2-5, <b ...[more]

PMID: 32790306

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