Ontology highlight
ABSTRACT:
SUBMITTER: Jones LH
PROVIDER: S-EPMC7460715 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Jones Lyn H LH Kelly Jeffery W JW
RSC medicinal chemistry 20200106 1
The discerning reactivity of sulfur(vi)-fluoride exchange (SuFEx) chemistry has enabled the context-specific labeling of protein binding sites by chemical probes that incorporate these versatile warheads. Emerging information from protein-probe structures and proteomic mapping experiments is helping advance our understanding of the protein microenvironment that dictates the reactivity of targetable amino acid residues. This review explores these new findings that should influence the future rati ...[more]