Ontology highlight
ABSTRACT:
SUBMITTER: Cruite JT
PROVIDER: S-EPMC9428674 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Cruite Justin T JT Dann Geoffrey P GP Che Jianwei J Donovan Katherine A KA Ferrao Silas S Ficarro Scott B SB Fischer Eric S ES Gray Nathanael S NS Huerta Fidel F Kong Nikki R NR Liu Hu H Marto Jarrod A JA Metivier Rebecca J RJ Nowak Radosław P RP Zerfas Breanna L BL Jones Lyn H LH
RSC chemical biology 20220708 9
Electrophilic biocompatible warheads, particularly cysteine-reactive acrylamides, have enabled the development of covalent inhibitor drugs and chemical biology probes, but cysteine is rarely present in protein binding sites. Therefore, expansion of the list of targetable amino acid residues is required to augment the synthetic bology toolkit of site-selective protein modifications. This work describes the first rational targeting of a specific histidine residue in a protein binding site using su ...[more]