Ontology highlight
ABSTRACT:
SUBMITTER: Gentile D
PROVIDER: S-EPMC7461590 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Gentile Davide D Fuochi Virginia V Rescifina Antonio A Furneri Pio Maria PM
International journal of molecular sciences 20200814 16
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has created a severe global health crisis. In this paper, we used docking and simulation methods to identify potential targets and the mechanism of action of chloroquine (CQ) and hydroxychloroquine (HCQ) against SARS-CoV-2. Our results showed that both CQ and HCQ influenced the functionality of the envelope (E) protein, necessary in the maturation processes of the virus, due to interactions that modify the flexibili ...[more]