Ontology highlight
ABSTRACT:
SUBMITTER: Cohan MC
PROVIDER: S-EPMC7462041 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Cohan Megan C MC Ruff Kiersten M KM Pappu Rohit V RV
Protein engineering, design & selection : PEDS 20191201 4
Intrinsically disordered proteins (IDPs) contribute to a multitude of functions. De novo design of IDPs should open the door to modulating functions and phenotypes controlled by these systems. Recent design efforts have focused on compositional biases and specific sequence patterns as the design features. Analysis of the impact of these designs on sequence-function relationships indicates that individual sequence/compositional parameters are insufficient for describing sequence-function relation ...[more]