Relating sequence encoded information to form and function of intrinsically disordered proteins.
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ABSTRACT:
SUBMITTER: Das RK
PROVIDER: S-EPMC4512920 | biostudies-literature | 2015 Jun
REPOSITORIES: biostudies-literature
Publications
Relating sequence encoded information to form and function of intrinsically disordered proteins.
Das Rahul K RK Ruff Kiersten M KM Pappu Rohit V RV
Current opinion in structural biology 20150402
Intrinsically disordered proteins (IDPs) showcase the importance of conformational plasticity and heterogeneity in protein function. We summarize recent advances that connect information encoded in IDP sequences to their conformational properties and functions. We focus on insights obtained through a combination of atomistic simulations and biophysical measurements that are synthesized into a coherent framework using polymer physics theories. ...[more]
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