Relating sequence encoded information to form and function of intrinsically disordered proteins.

ABSTRACT: Intrinsically disordered proteins (IDPs) showcase the importance of conformational plasticity and heterogeneity in protein function. We summarize recent advances that connect information encoded in IDP sequences to their conformational properties and functions. We focus on insights obtained through a combination of atomistic simulations and biophysical measurements that are synthesized into a coherent framework using polymer physics theories.

SUBMITTER: Das RK 

PROVIDER: S-EPMC4512920 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature