Ontology highlight
ABSTRACT:
SUBMITTER: Ma D
PROVIDER: S-EPMC7462304 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Ma Dong D Zheng Bin B Liu He-Liang HL Zhao Yong-Bo YB Liu Xiao X Zhang Xin-Hua XH Li Qiang Q Shi Wei-Bo WB Suzuki Toru T Wen Jin-Kun JK
PLoS biology 20200820 8
Although dysregulation of mitochondrial dynamics has been linked to cellular senescence, which contributes to advanced age-related disorders, it is unclear how Krüppel-like factor 5 (Klf5), an essential transcriptional factor of cardiovascular remodeling, mediates the link between mitochondrial dynamics and vascular smooth muscle cell (VSMC) senescence. Here, we show that Klf5 down-regulation in VSMCs is correlated with rupture of abdominal aortic aneurysm (AAA), an age-related vascular disease. ...[more]