Ontology highlight
ABSTRACT:
SUBMITTER: Raveendran M
PROVIDER: S-EPMC7463249 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Raveendran Mukhil M Lee Andrew J AJ Sharma Rajan R Wälti Christoph C Actis Paolo P
Nature communications 20200901 1
The ability to detect low concentrations of biomarkers in patient samples is one of the cornerstones of modern healthcare. In general, biosensing approaches are based on measuring signals resulting from the interaction of a large ensemble of molecules with the sensor. Here, we report a biosensor platform using DNA origami featuring a central cavity with a target-specific DNA aptamer coupled with a nanopore read-out to enable individual biomarker detection. We show that the modulation of the ion ...[more]