Association between ALMS 1 variants and early-onset coronary artery disease: a case-control study in Chinese population.

ABSTRACT:

Background

Genome-wide linkage analysis revealed the polymorphism of rs6748040 and glutamic acid repeat are potential pathogenic factors of early-onset myocardial infarction (MI). The present study was designed to investigate the associations of Alström syndrome 1 (ALMS 1) gene in Chinese populations with early-onset coronary artery disease (CAD).

Methods

The two variants of the ALMS 1 gene were genotyped in 1252 early-onset CAD patients and 1378 controls using PCR, followed by Sml I restriction enzyme digestion or direct sequencing of the PCR product. The associations were estimated using the odds ratio (OR) and the 95% confidence interval (CI).

Results

A significant association between the ALMS 1 G/A variant and the risk of early-onset MI was detected in G vs.A (OR

SUBMITTER: Zhang SY 

PROVIDER: S-EPMC7463302 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature