Identification and Characterization of Copy Number-Associated Driver Genes in Esophageal Squamous Cell Carcinoma.

ABSTRACT:

Background

Esophageal squamous cell carcinoma (ESCC) is a leading malignancy with both high incidence and mortality worldwide. However, the molecular mechanisms of the poor prognosis in ESCC are still unclear.

Methods

We conducted differential expression analysis between ESCC and normal tissues and between ESCC samples with and without CNAs in a given gene. Overrepresentation enrichment and gene set enrichment analyses were used to identify the oncogenic pathways and abnormal transcription factors (TFs). The survival analysis was employed to identify the genes associated with overall survival.

Results

In this study, we aimed to identify and interpret the driver genes triggered by the copy number alterations (CNAs), including CCND1, TEAD4, EIF4EBP1, EGFR, FGFR3, and FZ

SUBMITTER: Jiang K 

PROVIDER: S-EPMC7463369 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature