Ontology highlight
ABSTRACT:
SUBMITTER: Peronne L
PROVIDER: S-EPMC7463452 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Peronne Lauralie L Denarier Eric E Rai Ankit A Prudent Renaud R Vernet Audrey A Suzanne Peggy P Ramirez-Rios Sacnicté S Michallet Sophie S Guidetti Mélanie M Vollaire Julien J Lucena-Agell Daniel D Ribba Anne-Sophie AS Josserand Véronique V Coll Jean-Luc JL Dallemagne Patrick P Díaz J Fernando JF Oliva María Ángela MÁ Sadoul Karin K Akhmanova Anna A Andrieux Annie A Lafanechère Laurence L
Cancers 20200806 8
Paclitaxel is a microtubule stabilizing agent and a successful drug for cancer chemotherapy inducing, however, adverse effects. To reduce the effective dose of paclitaxel, we searched for pharmaceutics which could potentiate its therapeutic effect. We screened a chemical library and selected Carba1, a carbazole, which exerts synergistic cytotoxic effects on tumor cells grown in vitro, when co-administrated with a low dose of paclitaxel. Carba1 targets the colchicine binding-site of tubulin and i ...[more]