Ontology highlight
ABSTRACT:
SUBMITTER: Martinez JD
PROVIDER: S-EPMC7463913 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Martínez J Daniel JD Infantino Angela S AS Valverde Pablo P Diercks Tammo T Delgado Sandra S Reichardt Niels-Christian NC Ardá Ana A Cañada Francisco Javier FJ Oscarson Stefan S Jiménez-Barbero Jesús J
Pharmaceuticals (Basel, Switzerland) 20200804 8
Fluorinated glycomimetics are frequently employed to study and eventually modulate protein-glycan interactions. However, complex glycans and their glycomimetics may display multiple binding epitopes that enormously complicate the access to a complete picture of the protein-ligand complexes. We herein present a new methodology based on the synergic combination of experimental <sup>19</sup>F-based saturation transfer difference (STD) NMR data with computational protocols, applied to analyze the in ...[more]