Ontology highlight
ABSTRACT:
SUBMITTER: Dorneles GP
PROVIDER: S-EPMC9349448 | biostudies-literature | 2022 Aug
REPOSITORIES: biostudies-literature
Dorneles Gilson P GP Teixeira Paula C PC da Silva Igor M IM Schipper Lucas L LL Santana Filho Paulo C PC Rodrigues Junior Luiz C LC Bonorino Cristina C Peres Alessandra A Fonseca Simone G SG Monteiro Marta C MC Boeck Carina R CR Eller Sarah S Oliveira Tiago F TF Wendland Eliana M EM Romão Pedro R T PRT
Journal of cellular physiology 20220627 8
Purinergic signaling modulates immune function and is involved in the immunopathogenesis of several viral infections. This study aimed to investigate alterations in purinergic pathways in coronavirus disease 2019 (COVID-19) patients. Mild and severe COVID-19 patients had lower extracellular adenosine triphosphate and adenosine levels, and higher cytokines than healthy controls. Mild COVID-19 patients presented lower frequencies of CD4<sup>+</sup> CD25<sup>+</sup> CD39<sup>+</sup> (activated/memo ...[more]