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Genetic Susceptibility of the Host in Virus-Induced Diabetes.

ABSTRACT: Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of target genes in VID. In this review, we describe the genetic susceptibility of the host based on studies in humans and VID animal models. Understanding the host genetic factors should contribute not only to revealing the mechanisms of VID development, but also in taking measures to prevent VID.

SUBMITTER: Mine K

PROVIDER: S-EPMC7464158 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Genetic Susceptibility of the Host in Virus-Induced Diabetes.

Mine Keiichiro K Yoshikai Yasunobu Y Takahashi Hirokazu H Mori Hitoe H Anzai Keizo K Nagafuchi Seiho S

Microorganisms 20200727 8

Enteroviruses, especially Coxsackie B viruses, are among the candidate environmental factors causative of type 1 diabetes. Host genetic factors have an impact on the development of virus-induced diabetes (VID). Host background, in terms of whether the host is prone to autoimmunity, should also be considered when analyzing the role of target genes in VID. In this review, we describe the genetic susceptibility of the host based on studies in humans and VID animal models. Understanding the host gen ...[more]

PMID: 32727064

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