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Host genetic susceptibility to severe dengue infection.

ABSTRACT: Epidemiological evidence indicates that host genetic factors are relevant and predispose DHF/DSS development. Here, we review the host genetic studies concerning human leucocyte antigens, antibody receptors, immune/inflammatory mediators, attachment molecules, cytokines and other factors exerting an immunoregulatory effect as well as the current genome-wide association studies. We also discuss some viewpoints on future challenges related to the design of safe and effective prevention and treatment options.

SUBMITTER: Lan NT 

PROVIDER: S-EPMC3317601 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature

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Host genetic susceptibility to severe dengue infection.

Lan Nguyen Thi Phuong NT   Hirayama Kenji K  

Tropical medicine and health 20111012 4 Suppl

Epidemiological evidence indicates that host genetic factors are relevant and predispose DHF/DSS development. Here, we review the host genetic studies concerning human leucocyte antigens, antibody receptors, immune/inflammatory mediators, attachment molecules, cytokines and other factors exerting an immunoregulatory effect as well as the current genome-wide association studies. We also discuss some viewpoints on future challenges related to the design of safe and effective prevention and treatme  ...[more]

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