Ontology highlight
ABSTRACT:
SUBMITTER: Sprooten J
PROVIDER: S-EPMC7464343 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Sprooten Jenny J De Wijngaert Pieter P Vanmeerbeerk Isaure I Martin Shaun S Vangheluwe Peter P Schlenner Susan S Krysko Dmitri V DV Parys Jan B JB Bultynck Geert G Vandenabeele Peter P Garg Abhishek D AD
Cells 20200801 8
Immune-checkpoint blockers (ICBs) have revolutionized oncology and firmly established the subfield of immuno-oncology. Despite this renaissance, a subset of cancer patients remain unresponsive to ICBs due to widespread immuno-resistance. To "break" cancer cell-driven immuno-resistance, researchers have long floated the idea of therapeutically facilitating the immunogenicity of cancer cells by disrupting tumor-associated immuno-tolerance via conventional anticancer therapies. It is well appreciat ...[more]