Ontology highlight
ABSTRACT:
SUBMITTER: Cai Y
PROVIDER: S-EPMC7464562 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20200721 6511
Intervention strategies are urgently needed to control the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic. The trimeric viral spike (S) protein catalyzes fusion between viral and target cell membranes to initiate infection. Here, we report two cryo-electron microscopy structures derived from a preparation of the full-length S protein, representing its prefusion (2.9-angstrom resolution) and postfusion (3.0-angstrom resolution) conformations, respectively. The spontaneous t ...[more]