Dataset Information
Human platelets in presence of SARS-CoV-2 spike protein
Ontology highlight
ABSTRACT:
SUBMITTER: Christopher Cyrus Kuhn
PROVIDER: EMPIAR-11038 | biostudies-other |
REPOSITORIES: biostudies-other
Publications
Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 spike protein.
Nature communications 20230204 1
SARS-CoV-2 is a novel coronavirus responsible for the COVID-19 pandemic. Its high pathogenicity is due to SARS-CoV-2 spike protein (S protein) contacting host-cell receptors. A critical hallmark of COVID-19 is the occurrence of coagulopathies. Here, we report the direct observation of the interactions between S protein and platelets. Live imaging shows that the S protein triggers platelets to deform dynamically, in some cases, leading to their irreversible activation. Cellular cryo-electron tomo ...[more]
