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Human platelets in presence of SARS-CoV-2 spike protein

ABSTRACT:

SUBMITTER: Christopher Cyrus Kuhn

PROVIDER: EMPIAR-11038 | biostudies-other |

REPOSITORIES: biostudies-other

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Direct Cryo-ET observation of platelet deformation induced by SARS-CoV-2 spike protein.

Kuhn Christopher Cyrus CC Basnet Nirakar N Bodakuntla Satish S Alvarez-Brecht Pelayo P Nichols Scott S Martinez-Sanchez Antonio A Agostini Lorenzo L Soh Young-Min YM Takagi Junichi J Biertümpfel Christian C Mizuno Naoko N

Nature communications 20230204 1

SARS-CoV-2 is a novel coronavirus responsible for the COVID-19 pandemic. Its high pathogenicity is due to SARS-CoV-2 spike protein (S protein) contacting host-cell receptors. A critical hallmark of COVID-19 is the occurrence of coagulopathies. Here, we report the direct observation of the interactions between S protein and platelets. Live imaging shows that the S protein triggers platelets to deform dynamically, in some cases, leading to their irreversible activation. Cellular cryo-electron tomo ...[more]

PMID: 36739444

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