Ontology highlight
ABSTRACT:
SUBMITTER: Lucarini E
PROVIDER: S-EPMC7464824 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Lucarini Elena E Parisio Carmen C Branca Jacopo J V JJV Segnani Cristina C Ippolito Chiara C Pellegrini Carolina C Antonioli Luca L Fornai Matteo M Micheli Laura L Pacini Alessandra A Bernardini Nunzia N Blandizzi Corrado C Ghelardini Carla C Di Cesare Mannelli Lorenzo L
Cells 20200724 8
The management of visceral pain is a major clinical problem in patients affected by gastrointestinal disorders. The poor knowledge about pain chronicization mechanisms prompted us to study the functional and morphological alterations of the gut and nervous system in the animal model of persistent visceral pain caused by 2,4-dinitrobenzenesulfonic acid (DNBS). This agent, injected intrarectally, induced a colonic inflammation peaking on day 3 and remitting progressively from day 7. In concomitanc ...[more]