Ontology highlight
ABSTRACT:
SUBMITTER: Hishinuma E
PROVIDER: S-EPMC7464968 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Hishinuma Eiji E Gutiérrez Rico Evelyn E Hiratsuka Masahiro M
Journal of clinical medicine 20200722 8
Fluoropyrimidine drugs (FPs), including 5-fluorouracil, tegafur, capecitabine, and doxifluridine, are among the most widely used anticancer agents in the treatment of solid tumors. However, severe toxicity occurs in approximately 30% of patients following FP administration, emphasizing the importance of predicting the risk of acute toxicity before treatment. Three metabolic enzymes, dihydropyrimidine dehydrogenase (DPD), dihydropyrimidinase (DHP), and β-ureidopropionase (β-UP), degrade FPs; henc ...[more]