Ontology highlight
ABSTRACT:
SUBMITTER: Ruzzo A
PROVIDER: S-EPMC5709672 | biostudies-literature | 2017 Oct
REPOSITORIES: biostudies-literature
Ruzzo A A Graziano F F Galli Fabio F Galli Francesca F Rulli E E Lonardi S S Ronzoni M M Massidda B B Zagonel V V Pella N N Mucciarini C C Labianca R R Ionta M T MT Bagaloni I I Veltri E E Sozzi P P Barni S S Ricci V V Foltran L L Nicolini M M Biondi E E Bramati A A Turci D D Lazzarelli S S Verusio C C Bergamo F F Sobrero A A Frontini L L Menghi M M Magnani M M
British journal of cancer 20170824 9
<h4>Background</h4>Dihydropyrimidine dehydrogenase (DPD) catabolises ∼85% of the administered dose of fluoropyrimidines. Functional DPYD gene variants cause reduced/abrogated DPD activity. DPYD variants analysis may help for defining individual patients' risk of fluoropyrimidine-related severe toxicity.<h4>Methods</h4>The TOSCA Italian randomised trial enrolled colon cancer patients for 3 or 6 months of either FOLFOX-4 or XELOX adjuvant chemotherapy. In an ancillary pharmacogenetic study, 10 DPY ...[more]