Ontology highlight
ABSTRACT:
SUBMITTER: Hofmann L
PROVIDER: S-EPMC7465186 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Hofmann Lilli L Sallinger Katja K Haudum Christoph C Smolle Maria M Heitzer Ellen E Moser Tina T Novy Michael M Gesson Kevin K Kroneis Thomas T Bauernhofer Thomas T El-Heliebi Amin A
Cancers 20200811 8
Novel androgen receptor (AR) signaling inhibitors have improved the treatment of castration-resistant prostate cancer (CRPC). Nonetheless, the effect of these drugs is often time-limited and eventually most patients become resistant due to various AR alterations. Although liquid biopsy approaches are powerful tools for early detection of such therapy resistances, most assays investigate only a single resistance mechanism. In combination with the typically low abundance of circulating biomarkers, ...[more]