Evaluating liquid biopsies for methylomic profiling of prostate cancer.

ABSTRACT:

Background

Liquid biopsies offer significant potential for informing on cancer progression and therapeutic resistance via minimally invasive serial monitoring of genetic alterations. Although the cancer epigenome is a central driving force in most neoplasia, the accuracy of monitoring the tumor methylome using liquid biopsies remains relatively unknown.

Objectives

to investigate how well two types of liquid biopsy (urine and blood) capture the prostate cancer methylome, and may thus serve as a non-invasive surrogate for studying the tumor epigenome.

Methods

A cohort of four metastatic treatment naïve prostate cancer (PCa) patients was selected. Matched biopsy cores (tumor and histologically matched-normal), post-DRE, pre-biopsy urine, and peripheral blood plasma were

SUBMITTER: Silva R 

PROVIDER: S-EPMC7574384 | biostudies-literature | 2020 Jun - Jul

REPOSITORIES: biostudies-literature