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Efficacy of Chest CT for COVID-19 Pneumonia in France.


ABSTRACT: Background The role and performance of chest CT in the diagnosis of the coronavirus disease 2019 (COVID-19) pandemic remains under active investigation. Purpose To evaluate the French national experience using Chest CT for COVID-19, results of chest CT and RT-PCR were compared together and with the final discharge diagnosis used as reference standard. Materials and Methods A structured CT scan survey (NCT04339686) was sent to 26 hospital radiology departments in France between March 2 and April 24 2020. These dates correspond to the peak of the national COVID-19 epidemic. Radiology departments were selected to reflect the estimated geographical prevalence heterogeneities of the epidemic. All symptomatic patients suspected of having a COVID-19 pneumonia who underwent within 48 hours both initial chest CT and at least one RT-PCR testing were included. The final discharge diagnosis, based on multiparametric items, was recorded. Data for each center were prospectively collected and gathered each week. Test efficacy was determined by using Mann-Whitney Test, Student's t-test, Chi-square test and Pearson's correlation. A p value <.05 determined statistical significance. Results Twenty-six of 26 hospital radiology departments responded to the survey with 7500 patients entered; 2652 did not have RT-PCR results or had unknown or excess delay between RT-PCR and CT. After exclusions, 4824 patients (mean age 64, ± 19 yrs, 2669 males) were included. Using final diagnosis as the reference, 2564 of the 4824 patients were positive for COVID-19 (53%). Sensitivity, specificity, NPV and PPV of chest CT for diagnosing COVID-19 were 2319/2564 (90%, 95% confidence interval [CI]: 89, 91), 2056/2260 (91%, 95%CI: 91, 92%), 2056/2300 (89%, 95%CI; 87, 90%) and 2319/2524 (92%, 95%CI 91, 93%) respectively. There was no significant difference for chest CT efficacy among the 26 geographically separate sites, each with varying amounts of disease prevalence. Conclusion Use of chest CT for the initial diagnosis and triage of suspected COVID-19 patients was successful.

SUBMITTER: Herpe G 

PROVIDER: S-EPMC7465292 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Efficacy of Chest CT for COVID-19 Pneumonia Diagnosis in France.

Herpe Guillaume G   Lederlin Mathieu M   Naudin Mathieu M   Ohana Mickaël M   Chaumoitre Kathia K   Gregory Jules J   Vilgrain Valérie V   Freitag Cornelia Anna CA   De Margerie-Mellon Constance C   Flory Violaine V   Ludwig Marie M   Mondot Lydiane L   Fitton Isabelle I   Jacquier Alexis Raymond Robert ARR   Ardilouze Paul P   Petit Isabelle I   Gervaise Alban A   Bayle Olivier O   Crombe Arielle A   Mekuko Sokeng Magloire M   Thomas Clément C   Henry Geraldine G   Bliah Virginie V   Le Tat Thomas T   Guillot Marc-Samir MS   Guillot Marc-Samir MS   Gendrin Paul P   Garetier Marc M   Bertolle Estelle E   Montagne Catherine C   Langlet Benjamin B   Kalaaji Abdulrazak A   Kayayan Hampar H   Desmots Florian F   Dhaene Benjamin B   Saulnier Pierre-Jean PJ   Guillevin Remy R   Guillevin Remy R   Bartoli Jean-Michel JM   Beregi Jean-Paul JP   Tasu Jean Pierre JP  

Radiology 20200901 2


Background The role and performance of chest CT in the diagnosis of the coronavirus disease 2019 (COVID-19) pandemic remains under active investigation. Purpose To evaluate the French national experience using chest CT for COVID-19, results of chest CT and reverse transcription polymerase chain reaction (RT-PCR) assays were compared together and with the final discharge diagnosis used as the reference standard. Materials and Methods A structured CT scan survey (NCT04339686) was sent to 26 hospit  ...[more]

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