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COVID-19 pneumonia: high diagnostic accuracy of chest CT in patients with intermediate clinical probability.


ABSTRACT:

Objectives

To assess inter-reader agreements and diagnostic accuracy of chest CT to identify COVID-19 pneumonia in patients with intermediate clinical probability during an acute disease outbreak.

Methods

From March 20 to April 8, 319 patients (mean age 62.3 years old) consecutive patients with an intermediate clinical probability of COVID-19 pneumonia underwent a chest CT scan. Two independent chest radiologists blinded to clinical information and RT-PCR results retrospectively reviewed and classified images on a 1-5 confidence level scale for COVID-19 pneumonia. Agreements between radiologists were assessed with kappa statistics. Diagnostic accuracy of chest CT compared with RT-PCR assay and patient outcomes was measured using receiver operating characteristics (ROC). Positive predictive value (PPV) and negative predictive value (NPV) for COVID-19 pneumonia were calculated.

Results

Inter-observer agreement for highly probable (kappa: 0.83 [p?ConclusionDuring acute COVID-19 outbreak, chest CT scan may be used for triage of patients with intermediate clinical probability with very good inter-observer agreements and diagnostic accuracy.

Key points

• Concordances between two chest radiologists to diagnose or exclude a COVID-19 pneumonia in 319 consecutive patients with intermediate clinical probability were very good (kappa: 0.82; p?

SUBMITTER: Brun AL 

PROVIDER: S-EPMC7532930 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Publications

COVID-19 pneumonia: high diagnostic accuracy of chest CT in patients with intermediate clinical probability.

Brun Anne Laure AL   Gence-Breney Alexia A   Trichereau Julie J   Ballester Marie Christine MC   Vasse Marc M   Chabi Marie Laure ML   Mellot François F   Grenier Philippe A PA  

European radiology 20201003 4


<h4>Objectives</h4>To assess inter-reader agreements and diagnostic accuracy of chest CT to identify COVID-19 pneumonia in patients with intermediate clinical probability during an acute disease outbreak.<h4>Methods</h4>From March 20 to April 8, 319 patients (mean age 62.3 years old) consecutive patients with an intermediate clinical probability of COVID-19 pneumonia underwent a chest CT scan. Two independent chest radiologists blinded to clinical information and RT-PCR results retrospectively r  ...[more]

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