Ontology highlight
ABSTRACT:
SUBMITTER: Emmanouilidi A
PROVIDER: S-EPMC7465469 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Emmanouilidi Aikaterini A Casari Ilaria I Gokcen Akkaya Begum B Maffucci Tania T Furic Luc L Guffanti Federica F Broggini Massimo M Chen Xi X Maxuitenko Yulia Y YY Keeton Adam B AB Piazza Gary A GA Linton Kenneth J KJ Falasca Marco M
Cancers 20200723 8
Expression of ATP-binding cassette (ABC) transporters has long been implicated in cancer chemotherapy resistance. Increased expression of the ABCC subfamily transporters has been reported in prostate cancer, especially in androgen-resistant cases. ABCC transporters are known to efflux drugs but, recently, we have demonstrated that they can also have a more direct role in cancer progression. The pharmacological potential of targeting ABCC1, however, remained to be assessed. In this study, we inve ...[more]