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The Prowess of Andrographolide as a Natural Weapon in the War against Cancer.

ABSTRACT: There has been a paradigm shift in our understanding about the multifaceted nature of cancer, and a wealth of information has revealed that single-target drugs are not good enough to provide satisfactory clinical outcomes and therapeutic effects for complex diseases which involve multiple factors. Therefore, there has been a reignition to search for natural products having premium pharmacological activities aim to efficiently target multiple deregulated cellular signaling pathways. Andrographolide, a diterpene lactone from Andrographis paniculata was brought into to the limelight because of its ability to inhibit cancer cell proliferation and induce apoptosis. Here we reviewed andrographolide on cellular pathways regulation including Wnt/?-catenin, mTOR, VEGF-mediated intracellular signaling, as well as TRAIL-mediated apoptosis to inhibit cancer development.

SUBMITTER: Farooqi AA

PROVIDER: S-EPMC7465495 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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The Prowess of Andrographolide as a Natural Weapon in the War against Cancer.

Farooqi Ammad Ahmad AA Farooqi Ammad Ahmad AA Attar Rukset R Sabitaliyevich Uteuliyev Yerzhan UY Alaaeddine Nada N de Sousa Damião Pergentino DP Xu Baojun B Cho William C WC

Cancers 20200804 8

There has been a paradigm shift in our understanding about the multifaceted nature of cancer, and a wealth of information has revealed that single-target drugs are not good enough to provide satisfactory clinical outcomes and therapeutic effects for complex diseases which involve multiple factors. Therefore, there has been a reignition to search for natural products having premium pharmacological activities aim to efficiently target multiple deregulated cellular signaling pathways. Andrographoli ...[more]

PMID: 32759728

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