Ontology highlight
ABSTRACT:
SUBMITTER: Geant PY
PROVIDER: S-EPMC7466164 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Geant Pierre-Yves PY Uttaro Jean-Pierre JP Périgaud Christian C Mathé Christophe C
Molecules (Basel, Switzerland) 20200814 16
Carbocyclic nucleoside analogues are an essential class of antiviral agents and are commonly used in the treatment of viral diseases (hepatitis B, AIDS). Recently, we reported the racemic synthesis and the anti-human immunodeficiency virus activities (HIV) of 3'-fluoro-5'-norcarbocyclic nucleoside phosphonates bearing purines as heterocyclic base. Based on these results, the corresponding racemic norcarbocyclic nucleoside phosphonates bearing pyrimidine bases were synthesized. The prepared compo ...[more]