Ontology highlight
ABSTRACT:
SUBMITTER: Kasthuri M
PROVIDER: S-EPMC7143966 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20200311 6
Nucleoside analogs are widely used for the treatment of viral diseases (Hepatitis B/C, herpes and human immunodeficiency virus, HIV) and various malignancies. ALS-8176, a prodrug of the 4'-chloromethyl-2'-deoxy-2'-fluoro nucleoside ALS-8112, was evaluated in hospitalized infants for the treatment of respiratory syncytial virus (RSV), but was abandoned for unclear reasons. Based on the structure of ALS-8112, a series of novel 4'-modified-2'-deoxy-2'-fluoro nucleosides were synthesized. Newly prep ...[more]