Browse
Submit Data
Databases
API
Help

Dataset Information

15 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Photonic crystal based biosensors: Emerging inverse opals for biomarker detection.

ABSTRACT: Photonic crystal (PC)-based inverse opal (IO) arrays are one of the substrates for label-free sensing mechanism. IO-based materials with their advanced and ordered three-dimensional microporous structures have recently found attractive optical sensor and biological applications in the detection of biomolecules like proteins, DNA, viruses, etc. The unique optical and structural properties of IO materials can simplify the improvements in non-destructive optical study capabilities for point of care testing (POCT) used within a wide variety of biosensor research. In this review, which is an interdisciplinary investigation among nanotechnology, biology, chemistry and medical sciences, the recent fabrication methodologies and the main challenges regarding the application of (inverse opals) IOs in terms of their bio-sensing capability are summarized.

SUBMITTER: Fathi F

PROVIDER: S-EPMC7466948 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Photonic crystal based biosensors: Emerging inverse opals for biomarker detection.

Fathi Farzaneh F Rashidi Mohammad-Reza MR Pakchin Parvin Samadi PS Ahmadi-Kandjani Sohrab S Nikniazi Arash A

Talanta 20200902

Photonic crystal (PC)-based inverse opal (IO) arrays are one of the substrates for label-free sensing mechanism. IO-based materials with their advanced and ordered three-dimensional microporous structures have recently found attractive optical sensor and biological applications in the detection of biomolecules like proteins, DNA, viruses, etc. The unique optical and structural properties of IO materials can simplify the improvements in non-destructive optical study capabilities for point of care ...[more]

PMID: 33076145

Similar Datasets

Fluoropolymer-Containing Opals and Inverse Opals by Melt-Shear Organization.

Project description:The preparation of highly ordered colloidal architectures has attracted significant attention and is a rapidly growing field for various applications, e.g., sensors, absorbers, and membranes. A promising technique for the preparation of elastomeric inverse opal films relies on tailored core/shell particle architectures and application of the so-called melt-shear organization technique. Within the present work, a convenient route for the preparation of core/shell particles featuring highly fluorinated shell materials as building blocks is described. As particle core materials, both organic or inorganic (SiO?) particles can be used as a template, followed by a semi-continuous stepwise emulsion polymerization for the synthesis of the soft fluoropolymer shell material. The use of functional monomers as shell-material offers the possibility to create opal and inverse opal films with striking optical properties according to Bragg's law of diffraction. Due to the presence of fluorinated moieties, the chemical resistance of the final opals and inverse opals is increased. The herein developed fluorine-containing particle-based films feature a low surface energy for the matrix material leading to good hydrophobic properties. Moreover, the low refractive index of the fluoropolymer shell compared to the core (or voids) led to excellent optical properties based on structural colors. The herein described fluoropolymer opals and inverse opals are expected to pave the way toward novel functional materials for application in fields of coatings and optical sensors.

| S-EPMC6359200 | biostudies-literature

Photoelectrochemical detection of alpha-fetoprotein based on ZnO inverse opals structure electrodes modified by Ag2S nanoparticles.

Project description:In this work, a new photoelectrochemical biosensor based on Ag2S nanoparticles (NPs) modified macroporous ZnO inverse opals structure (IOs) was developed for sensitive and rapid detection of alpha fetal protein (AFP). Small size and uniformly dispersed Ag2S NPs were prepared using the Successive Ionic Layer Adsorption And Reaction (SILAR) method, which were adsorbed on ZnO IOs surface and frame work as matrix for immobilization of AFP. The composite structure of ZnO/Ag2S expanded the scope of light absorption to long wavelength, which can make full use of the light energy. Meanwhile, an effective matching of energy levels between the conduction bands of Ag2S and ZnO are beneficial to the photo-generated electrons transfer. The biosensors based on FTO (fluorine-doped tinoxide) ZnO/Ag2S electrode showed enough sensitivity and a wide linear range from 0.05?ng/mL to 200?ng/mL with a low detection limit of 8?pg/mL for the detection of AFP. It also exhibited high reproducibility, specificity and stability. The proposed method was potentially attractive for achieving excellent photoelectrochemical biosensor for detection of other proteins.

| S-EPMC5138818 | biostudies-other

Identifying modulators of protein-protein interactions using photonic crystal biosensors.

Project description:Inhibitors and activators of protein-protein interactions are valuable as biological probes and medicinal agents but are often difficult to identify. Herein we describe a high-throughput assay, based upon photonic crystal (PC) biosensors, for the identification of modulators of protein-protein interactions. Through the use of a d-biotin-tris-NTA (BTN) hybrid compound, any His6-tagged protein can be immobilized on the surface of a PC biosensor. Binding of the bound protein to its cognate partner is detected via a shift in the peak wavelength value. We demonstrate this assay with three protein-protein pairs (caspase-9-XIAP, caspase-7-XIAP, FKBP12-FRB) and their small molecule modulators.

| S-EPMC2799191 | biostudies-literature

Selective and Colorimetric Detection of p-Nitrophenol Based on Inverse Opal Polymeric Photonic Crystals.

Project description:The detection of p-nitrophenol (PNP) is of great significance for assessment of environment pollution and potential health risks. In this study, based on inverse opal polymeric photonic crystals (IOPPCs), a selective and visual sensor for high-performance PNP detection is developed. Due to their unique optical properties, IOPPCs report events by change of color, which can easily be observed by the naked eye. Hydroxyethyl methacrylate (HEMA) was selected as the functional monomer with which to fabricate the IOPPCs. By precisely adjusting the molar ratio between the functional monomer and the crosslinker, the sensors were only able to be sensitive to a specific solution, thus realizing the visual, selective, and semi-quantitative detection of PNP. When the sensors were immersed in different concentrations of PNP solution, their Bragg diffraction wavelengths showed different redshifts. The color of the IOPPCs changed from green to red as the peak shift of Bragg diffraction occurred. In addition, the IOPPCs displayed good interference immunity and reusability.

| S-EPMC7023634 | biostudies-literature

The Elaboration of Effective Coatings for Photonic Crystal Chips in Optical Biosensors.

Project description:Here, we propose and study several types of quartz surface coatings designed for the high-performance sorption of biomolecules and their subsequent detection by a photonic crystal surface mode (PC SM) biosensor. The deposition and sorption of biomolecules are revealed by analyzing changes in the propagation parameters of optical modes on the surface of a photonic crystal (PC). The method makes it possible to measure molecular and cellular affinity interactions in real time by independently recording the values of the angle of total internal reflection and the angle of excitation of the surface wave on the surface of the PC. A series of dextrans with various anchor groups (aldehyde, carboxy, epoxy) suitable for binding with bioligands have been studied. We have carried out comparative experiments with dextrans with other molecular weights. The results confirmed that dextran with a Mw of 500 kDa and anchor epoxy groups have a promising potential as a matrix for the detection of proteins in optical biosensors. The proposed approach would make it possible to enhance the sensitivity of the PC SM biosensor and also permit studying the binding process of low molecular weight molecules in real time.

| S-EPMC8747551 | biostudies-literature

Multi-solvent large stopband monitoring based on the insolubility/superoleophilicity of PEDOT inverse opals.

Project description:Monitoring and post-processing of organic solvents are important for environmental protection. Challenges remain in the development of a universal material which can detect any solvent with a large stopband shift and show excellent stability. Herein, we demonstrate a poly 3,4-ethylenedioxythiophene inverse opal (PEDOT-IO) with a large stopband shift toward various solvents based on the insolubility/superoleophilicity properties. The PEDOT-IO film was fabricated by the potentiostatic polymerization of 3,4-ethylene dioxythiophene using a three-electrode system, infiltrating the interstices of the photonic crystal template with PEDOT and subsequently removing the template. The surface of the PEDOT-IO film presented a composite structure: interconnected pores and hollow shells. When the solvent was introduced into the voids of PEDOT-IO film, the effective refractive index (n) of the whole sample increased due to the replacement of air with the solvent, and the pores and hollow shells showed different degrees of swelling. The synergistic effect of increased n and volume expansion contributed to a large redshift of the stopband of the PEDOT-IO film. PEDOT-IO film exhibited excellent resistance to various solvents and high/low temperature. This work further enriches the application of conductive polymers in solvent-responsive PC sensors and provides a novel means of creating PC-based optical materials and devices.

| S-EPMC8315103 | biostudies-literature

Evaluation of Silk Inverse Opals for "Smart" Tissue Culture.

Project description:Visually tracking the subtle aspects of biological systems in real time during tissue culture remains challenging. Herein, we demonstrate the use of bioactive, cytocompatible, and biodegradable inverse opals from silk as a multifunctional substrate to transduce both the optical information and cells during tissue culture. We show that these substrates can visually track substrate degradation in various proteases during tissue digestion and protein deposition during the growth of mesenchymal stem cells. Uniquely, these substrates can be integrated in multiple steps of tissue culture for simple-to-use, visual, and quantitative detectors of bioactivity. These substrates can also be doped, demonstrated here with gold nanoparticles, to allow additional control of cell functions.

| S-EPMC6044746 | biostudies-literature

Slow light enhanced sensitivity of resonance modes in photonic crystal biosensors.

Project description:We demonstrate experimentally that in photonic crystal sensors with a side-coupled cavity-waveguide configuration, group velocity of the propagating mode in the coupled waveguide at the frequency of the resonant mode plays an important role in enhancing the sensitivity. In linear L13 photonic crystal microcavities, with nearly same resonance mode quality factors ∼7000 in silicon-on-insulator devices, sensitivity increased from 57 nm/RIU to 66 nm/RIU as group index in the coupled waveguide increased from 10.2 to 13.2. Engineering for highest sensitivity in such planar integrated sensors, thus, requires careful slow light design for optimized sensor sensitivity.

| S-EPMC3574073 | biostudies-other

Microscale Liquid Transport in Polycrystalline Inverse Opals across Grain Boundaries.

Project description:Delivering liquid through the void spaces in porous metals is a daunting challenge for a variety of emerging interface technologies ranging from battery electrodes to evaporation surfaces. Hydraulic transport characteristics of well-ordered porous media are governed by the pore distribution, porosity, and morphology. Much like energy transport in polycrystalline solids, hydraulic transport in semi-ordered porous media is predominantly limited by defects and grain boundaries. Here, we report the wicking performances for porous copper inverse opals having pore diameters from 300 to 1000?nm by measuring the capillary-driven liquid rise. The capillary performance parameter within single crystal domain (K ij /R eff ?=?10-3 to 10-2?µm) is an order of magnitude greater than the collective polycrystal (K eff /R eff ?=?~10-5 to 10-3?µm) due to the hydraulic resistances (i.e. grain boundaries between individual grains). Inspired by the heterogeneity found in biological systems, we report that the capillary performance parameter of gradient porous copper (K eff /R eff ?=?~10-3?µm), comparable to that of single crystals, overcomes hydraulic resistances through providing additional hydraulic routes in three dimensions. The understanding of microscopic liquid transport physics through porous crystals and across grain boundaries will help to pave the way for the spatial design of next-generation heterogeneous porous media.

| S-EPMC5585244 | biostudies-literature

A general method for discovering inhibitors of protein-DNA interactions using photonic crystal biosensors.

Project description:Protein-DNA interactions are essential for fundamental cellular processes such as transcription, DNA damage repair, and apoptosis. As such, small molecule disruptors of these interactions could be powerful tools for investigation of these biological processes, and such compounds would have great potential as therapeutics. Unfortunately, there are few methods available for the rapid identification of compounds that disrupt protein-DNA interactions. Here we show that photonic crystal (PC) technology can be utilized to detect protein-DNA interactions, and can be used in a high-throughput screening mode to identify compounds that prevent protein-DNA binding. The PC technology is used to detect binding between protein-DNA interactions that are DNA-sequence-dependent (the bacterial toxin-antitoxin system MazEF) and those that are DNA-sequence-independent (the human apoptosis inducing factor (AIF)). The PC technology was further utilized in a screen for inhibitors of the AIF-DNA interaction, and through this screen aurin tricarboxylic acid was identified as the first in vitro inhibitor of AIF. The generality and simplicity of the photonic crystal method should enable this technology to find broad utility for identification of compounds that inhibit protein-DNA binding.

| S-EPMC2805019 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data