Dataset Information

Parabrachial neuron types categorically encode thermoregulation variables during heat defense.

ABSTRACT: Heat defense is crucial for survival and fitness. Transmission of thermosensory signals into hypothalamic thermoregulation centers represents a key layer of regulation in heat defense. Yet, how these signals are transmitted into the hypothalamus remains poorly understood. Here, we reveal that lateral parabrachial nucleus (LPB) glutamatergic prodynorphin and cholecystokinin neuron populations are progressively recruited to defend elevated body temperature. These two nonoverlapping neuron types form circuits with downstream preoptic hypothalamic neurons to inhibit the thermogenesis of brown adipose tissues (BATs) and activate tail vasodilation, respectively. Both circuits are activated by warmth and can limit fever development. The prodynorphin circuit is further required for regulating energy expenditure and body weight homeostasis. Thus, these findings establish that the genetic and functional specificity of heat defense neurons occurs as early as in the LPB and uncover categorical neuron types for encoding two heat defense variables, inhibition of BAT thermogenesis and activation of vasodilation.

SUBMITTER: Yang WZ

PROVIDER: S-EPMC7467693 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Parabrachial neuron types categorically encode thermoregulation variables during heat defense.

Yang Wen Z WZ Du Xiaosa X Zhang Wen W Gao Cuicui C Xie Hengchang H Xiao Yan Y Jia Xiaoning X Liu Jiashu J Xu Jianhui J Fu Xin X Tu Hongqing H Fu Xiaoyu X Ni Xinyan X He Miao M Yang Jiajun J Wang Hong H Yang Haitao H Xu Xiao-Hong XH Shen Wei L WL

Science advances 20200902 36

Heat defense is crucial for survival and fitness. Transmission of thermosensory signals into hypothalamic thermoregulation centers represents a key layer of regulation in heat defense. Yet, how these signals are transmitted into the hypothalamus remains poorly understood. Here, we reveal that lateral parabrachial nucleus (LPB) glutamatergic prodynorphin and cholecystokinin neuron populations are progressively recruited to defend elevated body temperature. These two nonoverlapping neuron types fo ...[more]

PMID: 32917598

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Dataset Information

Parabrachial neuron types categorically encode thermoregulation variables during heat defense.

Publications

Parabrachial neuron types categorically encode thermoregulation variables during heat defense.

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