Ontology highlight
ABSTRACT:
SUBMITTER: Li BZ
PROVIDER: S-EPMC7467729 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Li Bin-Zhong BZ Putnam Christopher D CD Kolodner Richard David RD
eLife 20200807
Foldback inversions, also called inverted duplications, have been observed in human genetic diseases and cancers. Here, we used a <i>Saccharomyces cerevisiae</i> genetic system that generates gross chromosomal rearrangements (GCRs) mediated by foldback inversions combined with whole-genome sequencing to study their formation. Foldback inversions were mediated by formation of single-stranded DNA hairpins. Two types of hairpins were identified: small-loop hairpins that were suppressed by <i>MRE11< ...[more]