Ontology highlight
ABSTRACT:
SUBMITTER: Pan KS
PROVIDER: S-EPMC7468408 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Pan Kylie S KS Siow Andrew A Hay Debbie L DL Walker Christopher S CS
Frontiers in pharmacology 20200820
The "gepants" are a class of calcitonin gene-related peptide (CGRP) receptor antagonist molecules that have been developed for the prevention and treatment of migraine. Rimegepant is reported to act at the CGRP receptor, has good oral bioavailability, and has had positive clinical trial results. However, there is very little data available describing its receptor pharmacology. Importantly, rimegepant activity at the AMY<sub>1</sub> receptor, a second potent CGRP receptor that is known to be expr ...[more]