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Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications for prognosis.

ABSTRACT: OBJECTIVE:Chronic lymphocytic leukemia (CLL) is an adult leukemia presented with clonal accumulation of lymphocytes. Immunophenotypic changes can be effective in predicting clinical course, the survival of patients, and determining first-line treatment. This is a study of the association between immunophenotypic markers with complete blood cell count (CBC) values and clinical parameters. RESULTS:Peripheral blood samples were collected from 35 newly diagnosed CLL patients. The expression of immunophenotypic markers and CBC were evaluated. Platelet counts and hemoglobin concentration had a significant, inverse association with Rai staging, modified Rai staging, Binet staging systems (all p?

SUBMITTER: Bagheri M

PROVIDER: S-EPMC7469386 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Evaluation of immunophenotypic markers and clinico-hematological profile in chronic lymphocytic leukemia: implications for prognosis.

Bagheri Marziye M Vosoughi Tina T Hosseinzadeh Mehran M Saki Najmaldin N

BMC research notes 20200903 1

<h4>Objective</h4>Chronic lymphocytic leukemia (CLL) is an adult leukemia presented with clonal accumulation of lymphocytes. Immunophenotypic changes can be effective in predicting clinical course, the survival of patients, and determining first-line treatment. This is a study of the association between immunophenotypic markers with complete blood cell count (CBC) values and clinical parameters.<h4>Results</h4>Peripheral blood samples were collected from 35 newly diagnosed CLL patients. The expr ...[more]

PMID: 32883360

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