HuR expression in adipose tissue mediates energy expenditure and acute thermogenesis independent of UCP1 expression.

ABSTRACT: The goal of this study was to define the functional role of adipocyte-specific expression of the RNA binding protein Human antigen R (HuR). Mice with an adipocyte-specific deletion of HuR (Adipo-HuR^-/- ) were generated by crossing HuR floxed (HuR^fl/fl ) mice with mice expressing adiponectin-driven cre-recombinase (Adipoq-cre). Our results show that Adipo-HuR^-/- mice display a lean phenotype compared to wild-type littermate controls. HuR deletion results in a diet-independent reduction in percent body fat composition along with an increase in energy expenditure. Functionally, Adipo-HuR^-/- mice show a significant impairment in acute adaptive thermogenesis (six hours at 4°C), but uncoupling protein 1 (UCP1) protein

SUBMITTER: Anthony SR 

PROVIDER: S-EPMC7469577 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature