The Association Between Genetic Polymorphisms in Estrogen Receptor Genes and the Risk of Ocular Disease: A Meta-Analysis

ABSTRACT:

Objectives

To evaluate the association between estrogen receptor (ER) genes polymorphisms and the risk of ocular disease.

Materials and methods

A meta-analysis was performed of all available studies that investigated the association between ER gene polymorphisms and the risk of ocular disease.

Results

Studies that were selected based on inclusion criteria reported 5 and 4 single-nucleotide polymorphisms (SNPs) identified in the ESR1 (ERα) (rs2234093, rs12154178, rs1884054, rs1801132, and rs9340799) and ESR2 (ERβ) (rs1268656, rs7159462, rs1256031, and rs4986938) genes, respectively. The pooled result showed a significant association between ESR2 rs1256031 gene polymorphism and ocular disease (odds ratio: 0.55, 95% confidence interval:

SUBMITTER: Ulhaq ZS 

PROVIDER: S-EPMC7469901 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature