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Observational study of azithromycin in hospitalized patients with COVID-19.

ABSTRACT: BACKGROUND:The rapid spread of the disease caused by the novel SARS-CoV-2 virus has led to the use of multiple therapeutic agents whose efficacy has not been previously demonstrated. The objective of this study was to analyze whether there is an association between the use of azithromycin and the evolution of the pulmonary disease or the time to discharge, in patients hospitalized with COVID-19. METHODS:This was an observational study on a cohort of 418 patients admitted to three regional hospitals in Catalonia, Spain. As primary outcomes, we studied the evolution of SAFI ratio (oxygen saturation/fraction of inspired oxygen) in the first 48 hours of treatment and the time to discharge. The results were compared between patients treated and untreated with the study drug through subcohort analyses matched for multiple clinical and prognostic factors, as well as through analysis of non-matched subcohorts, using Cox multivariate models adjusted for prognostic factors. RESULTS:There were 239 patients treated with azithromycin. Of these, 29 patients treated with azithromycin could be matched with an equivalent number of control patients. In the analysis of these matched subcohorts, SAFI at 48h had no significant changes associated to the use of azithromycin, though azithromycin treatment was associated with a longer time to discharge (10.0 days vs 6.7 days; log rank: p = 0.039). However, in the unmatched cohorts, the increased hospital stay associated to azithromycin use, was no significant after adjustment using Multivariate Cox regression models: hazard ratio 1.45 (IC95%: 0.88-2.41; p = 0.150). This study is limited by its small sample size and its observational nature; despite the strong pairing of the matched subcohorts and the adjustment of the Cox regression for multiple factors, the results may be affected by residual confusion. CONCLUSIONS:We did not find a clinical benefit associated with the use of azithromycin, in terms of lung function 48 hours after treatment or length of hospital stay.

SUBMITTER: Rodriguez-Molinero A

PROVIDER: S-EPMC7470304 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Observational study of azithromycin in hospitalized patients with COVID-19.

Rodríguez-Molinero Alejandro A Pérez-López Carlos C Gálvez-Barrón César C Miñarro Antonio A Macho Oscar O López Gabriela F GF Robles Maria Teresa MT Dapena María Dolores MD Martínez Sergi S Rodríguez Ezequiel E Collado Isabel I

PloS one 20200903 9

<h4>Background</h4>The rapid spread of the disease caused by the novel SARS-CoV-2 virus has led to the use of multiple therapeutic agents whose efficacy has not been previously demonstrated. The objective of this study was to analyze whether there is an association between the use of azithromycin and the evolution of the pulmonary disease or the time to discharge, in patients hospitalized with COVID-19.<h4>Methods</h4>This was an observational study on a cohort of 418 patients admitted to three ...[more]

PMID: 32881982

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Dataset Information

Observational study of azithromycin in hospitalized patients with COVID-19.

Publications

Observational study of azithromycin in hospitalized patients with COVID-19.

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