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Optimizing the Number of Child Deaths Averted with Mass Azithromycin Distribution.


ABSTRACT: Biannual mass azithromycin distribution to children younger than 5 years has been shown to reduce all-cause mortality in sub-Saharan Africa. Antibiotic-sparing approaches to azithromycin distribution, such as targeting to younger children who are at higher risk of mortality, are being considered by policymakers. We evaluated the absolute number of deaths averted in the Macrolides Oraux pour Réduire le Décès avec un Oeil sur la Résistance study in three age-groups: 1-5 months, 1-11 months, and 1-59 months. The number of deaths averted decreased from 729 (95% CI 492 to 966) in children aged 1-59 months to 297 (95% CI 168 to 427) and 126 (95% CI 43 to 209) in the 1- to 11-month and 1- to 5-month groups, respectively. Limiting antibiotic treatment to a subgroup of higher risk children may result in fewer deaths averted compared with treating all preschool children.

SUBMITTER: Oldenburg CE 

PROVIDER: S-EPMC7470533 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Optimizing the Number of Child Deaths Averted with Mass Azithromycin Distribution.

Oldenburg Catherine E CE   Arzika Ahmed M AM   Maliki Ramatou R   Lin Ying Y   O'Brien Kieran S KS   Keenan Jeremy D JD   Lietman Thomas M TM   For The Mordor Study Group  

The American journal of tropical medicine and hygiene 20200901 3


Biannual mass azithromycin distribution to children younger than 5 years has been shown to reduce all-cause mortality in sub-Saharan Africa. Antibiotic-sparing approaches to azithromycin distribution, such as targeting to younger children who are at higher risk of mortality, are being considered by policymakers. We evaluated the absolute number of deaths averted in the <i>Macrolides Oraux pour Réduire le Décès avec un Oeil sur la Résistance</i> study in three age-groups: 1-5 months, 1-11 months,  ...[more]

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