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Effect Modification by Baseline Mortality in the MORDOR Azithromycin Trial.


ABSTRACT: We examined whether baseline mortality risk, as a function of child age and site, modified the azithromycin mortality-reduction effect in the Macrolide Oraux pour Réduire les Décès avec un Oeil sur la Résistance (MORDOR) clinical trial. We used the Cox proportional hazards model with an interaction term. Three models were examined representing three sources for the baseline-risk covariate: two using sources external to MORDOR and the third leveraging data within MORDOR. All three models provided moderate evidence for the effect becoming stronger with increasing baseline mortality (P = 0.02, 0.02, and 0.07, respectively) at the rate of approximately 6-12% additional mortality reduction per doubling of baseline mortality. Etiological and programmatic implications of these findings are discussed.

SUBMITTER: Oron AP 

PROVIDER: S-EPMC7470539 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Effect Modification by Baseline Mortality in the MORDOR Azithromycin Trial.

Oron Assaf P AP   Burstein Roy R   Mercer Laina D LD   Arzika Ahmed M AM   Kalua Khumbo K   Mrango Zakayo Z   West Sheila K SK   Bailey Robin L RL   Porco Travis C TC   Lietman Thomas M TM  

The American journal of tropical medicine and hygiene 20200901 3


We examined whether baseline mortality risk, as a function of child age and site, modified the azithromycin mortality-reduction effect in the <i>Macrolide Oraux pour Réduire les Décès avec un Oeil sur la Résistance</i> (MORDOR) clinical trial. We used the Cox proportional hazards model with an interaction term. Three models were examined representing three sources for the baseline-risk covariate: two using sources external to MORDOR and the third leveraging data within MORDOR. All three models p  ...[more]

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