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Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial.


ABSTRACT: In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981.

SUBMITTER: Porco TC 

PROVIDER: S-EPMC6541729 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

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Mass Oral Azithromycin for Childhood Mortality: Timing of Death After Distribution in the MORDOR Trial.

Porco Travis C TC   Hart John J   Arzika Ahmed M AM   Weaver Jerusha J   Kalua Khumbo K   Mrango Zakayo Z   Cotter Sun Y SY   Stoller Nicole E NE   O'Brien Kieran S KS   Fry Dionna M DM   Vanderschelden Benjamin B   Oldenburg Catherine E CE   West Sheila K SK   Bailey Robin L RL   Keenan Jeremy D JD   Lietman Thomas M TM  

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20190501 12


In a large community-randomized trial, biannual azithromycin distributions significantly reduced postneonatal childhood mortality in sub-Saharan African sites. Here, we present a prespecified secondary analysis showing that much of the protective effect was in the first 3 months postdistribution. Distributing more frequently than biannually could be considered if logistically feasible. Clinical Trials Registration. NCT02047981. ...[more]

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