Ontology highlight
ABSTRACT:
SUBMITTER: Green R
PROVIDER: S-EPMC7470746 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Green Robin R Sonal Wang Lin L Hart Samuel F M SFM Lu Wenyun W Skelding David D Burton Justin C JC Mi Hanbing H Capel Aric A Chen Hung Alex HA Lin Aaron A Subramaniam Arvind R AR Rabinowitz Joshua D JD Shou Wenying W
PLoS biology 20200824 8
In eukaryotes, conserved mechanisms ensure that cell growth is coordinated with nutrient availability. Overactive growth during nutrient limitation ("nutrient-growth dysregulation") can lead to rapid cell death. Here, we demonstrate that cells can adapt to nutrient-growth dysregulation by evolving major metabolic defects. Specifically, when yeast lysine-auxotrophic mutant lys- encountered lysine limitation, an evolutionarily novel stress, cells suffered nutrient-growth dysregulation. A subpopula ...[more]