Ontology highlight
ABSTRACT:
SUBMITTER: Kolberg L
PROVIDER: S-EPMC7470823 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Kolberg Liis L Kerimov Nurlan N Peterson Hedi H Alasoo Kaur K
eLife 20200903
Understanding the causal processes that contribute to disease onset and progression is essential for developing novel therapies. Although <i>trans</i>-acting expression quantitative trait loci (<i>trans</i>-eQTLs) can directly reveal cellular processes modulated by disease variants, detecting <i>trans</i>-eQTLs remains challenging due to their small effect sizes. Here, we analysed gene expression and genotype data from six blood cell types from 226 to 710 individuals. We used co-expression modul ...[more]