Ontology highlight
ABSTRACT:
SUBMITTER: Van Dyke K
PROVIDER: S-EPMC8611878 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Van Dyke Krisna K Lutz Sheila S Mekonnen Gemechu G Myers Chad L CL Albert Frank W FW
Genetics 20210301 3
Gene expression differences among individuals are shaped by trans-acting expression quantitative trait loci (eQTLs). Most trans-eQTLs map to hotspot locations that influence many genes. The molecular mechanisms perturbed by hotspots are often assumed to involve "vertical" cascades of effects in pathways that can ultimately affect the expression of thousands of genes. Here, we report that trans-eQTLs can affect the expression of adjacent genes via "horizontal" mechanisms that extend along a chrom ...[more]