Ontology highlight
ABSTRACT:
SUBMITTER: Bernreuther C
PROVIDER: S-EPMC7471174 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Pathology oncology research : POR 20200716 4
Secreted frizzled-related protein 4 (SFRP4) controls WNT signaling and is thought to play a role for tumor aggressiveness. Here, we analyzed a tissue microarray containing 11,152 prostate cancers with pathological, clinical and molecular data by immunohistochemistry. SFRP4 expression was higher in cancer than in non-neoplastic acinar cells. SFRP4 staining was seen in 64.9% of tumors and classified as weak in 33.2%, moderate in 23.9% and strong in 7.8% of cancers. SFRP4 overexpression was linked ...[more]