Dataset Information

Secreted Frizzled-Related Protein 4 (SFRP4) Is an Independent Prognostic Marker in Prostate Cancers Lacking TMPRSS2: ERG Fusions.

ABSTRACT: Secreted frizzled-related protein 4 (SFRP4) controls WNT signaling and is thought to play a role for tumor aggressiveness. Here, we analyzed a tissue microarray containing 11,152 prostate cancers with pathological, clinical and molecular data by immunohistochemistry. SFRP4 expression was higher in cancer than in non-neoplastic acinar cells. SFRP4 staining was seen in 64.9% of tumors and classified as weak in 33.2%, moderate in 23.9% and strong in 7.8% of cancers. SFRP4 overexpression was linked to advanced tumor stage, high classical/quantitative Gleason grade (p?

SUBMITTER: Bernreuther C

PROVIDER: S-EPMC7471174 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Secreted Frizzled-Related Protein 4 (SFRP4) Is an Independent Prognostic Marker in Prostate Cancers Lacking TMPRSS2: ERG Fusions.

Bernreuther Christian C Daghigh Ferdous F Möller Katharina K Hube-Magg Claudia C Lennartz Maximilian M Lutz Florian F Rico Sebastian Dwertmann SD Fraune Christoph C Dum David D Luebke Andreas M AM Eichenauer Till T Möller-Koop Christina C Schlomm Thorsten T Wittmer Corinna C Huland Hartwig H Heinzer Hans H Graefen Markus M Haese Alexander A Burandt Eike E Tsourlakis Maria Christina MC Clauditz Till S TS Höflmayer Doris D Izbicki Jakob R JR Simon Ronald R Sauter Guido G Minner Sarah S Steurer Stefan S Meiners Jan J

Pathology oncology research : POR 20200716 4

Secreted frizzled-related protein 4 (SFRP4) controls WNT signaling and is thought to play a role for tumor aggressiveness. Here, we analyzed a tissue microarray containing 11,152 prostate cancers with pathological, clinical and molecular data by immunohistochemistry. SFRP4 expression was higher in cancer than in non-neoplastic acinar cells. SFRP4 staining was seen in 64.9% of tumors and classified as weak in 33.2%, moderate in 23.9% and strong in 7.8% of cancers. SFRP4 overexpression was linked ...[more]

PMID: 32677026

Dataset Information

Secreted Frizzled-Related Protein 4 (SFRP4) Is an Independent Prognostic Marker in Prostate Cancers Lacking TMPRSS2: ERG Fusions.

Publications

Secreted Frizzled-Related Protein 4 (SFRP4) Is an Independent Prognostic Marker in Prostate Cancers Lacking TMPRSS2: ERG Fusions.

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