Ontology highlight
ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC7471343 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Liu Lixin L Pan Yangjian Y Ren Xiaoli X Zeng Zhicheng Z Sun Jingbo J Zhou Kun K Liang Yunshi Y Wang Feifei F Yan Yongrong Y Liao Wenting W Ding Yanqing Y Liu Xiaolong X Liang Li L
American journal of cancer research 20200801 8
As a rate-limiting enzyme of the hexosamine biosynthesis pathway (HBP), which is responsible for glycosylation, Glutamine fructose-6-phosphate amidotransferase 2 (GFPT2) is involved in human breast and lung tumorigenesis. However, whether GFTP2 is associated with tumor metastasis remains unclear. Here, we found that GFPT2 promoted the proliferation, migration, invasion and metastasis of colorectal cancer (CRC) cells. Mechanically, p65 acted as an upstream transcription factor of GFPT2 and regula ...[more]