Ontology highlight
ABSTRACT:
SUBMITTER: Nemlich Y
PROVIDER: S-EPMC7471345 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Nemlich Yael Y Besser Michal J MJ Schachter Jacob J Markel Gal G
American journal of cancer research 20200801 8
Melanoma cells utilize multiple mechanisms to exit the primary tumor mass, invade the surroundings and subsequently distant tissues. We have previously reported that the expression of the RNA editing enzyme ADAR1 (adenosine deaminase acting on RNA) is downregulated in metastatic melanoma, which facilitates proliferation and invasion. Here we show that ADAR1 controls melanoma invasiveness by regulating ITGB3 expression via miR-30a and miR-30d. ADAR1 overexpression or knockdown leads to an increas ...[more]